Do New Protease Inhibitors Offer Improved Clincial Effectiveness?

Summarizes the potency and efficacy of new protease inhibitors in representing a major change in the approach to the treatment of HIV-1 infection and AIDS. Consideration of protease inhibitors, atazanavir and fosamprenavir as promising options for initial antiretroviral therapy; Contribution of the use of HIV-1 protease inhibitors to teh significant decline in morbidity and mortality associated with HIV infection and AIDS.