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Anti-allergic activity of 3, 5, 6, 7, 8, 3′, 4′-heptamethoxyflavone extracted from Citri Reticulatae Pericarpium.
- Source :
-
Spectroscopy Letters . 2018, Vol. 51 Issue 5, p236-243. 8p. - Publication Year :
- 2018
-
Abstract
- The inhibitory activity of 3, 5, 6, 7, 8, 3′, 4′-heptamethoxyflavone extracted from Citri Reticulatae Pericarpium on RBL-2H3 cells degranulation was done by two different methods. At low concentration, the values of inhibition obtained by modified method were much larger than that of the classical method. Spectroscopic measurements and molecular docking calculation were applied to study the mechanism. It was induced by interaction between flavonoid and immunoglobulin E. Compared with the interaction between antibody and receptor, the force was weak, the inhibitory effect on β-hexosaminidase release was strong, with some structural changes to the antibody. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00387010
- Volume :
- 51
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Spectroscopy Letters
- Publication Type :
- Academic Journal
- Accession number :
- 130021290
- Full Text :
- https://doi.org/10.1080/00387010.2018.1455707