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Cytotoxic triterpenoid saponins from the defatted seeds of Camellia oleifera Abel.
- Source :
-
Journal of Asian Natural Products Research . May2018, Vol. 20 Issue 5, p412-422. 11p. - Publication Year :
- 2018
-
Abstract
- Five new oleanane-type triterpenoid saponins, oleiferasaponins D1-D5 (1-5), were isolated from the defatted seeds of Camellia oleifera Abel. Their structures were elucidated by spectroscopic and chemical methods. The cytotoxic activities of compounds 1-5 were evaluated against five human tumor cell lines (HCT-116, HepG2, BGC-823, NCI-H1650, and A2780). Compounds 1-2 exhibited cytotoxic activity against five human cancer cell lines, with IC50 values ranging from 3.31 to 10.23 μM. Compounds 3-5 showed moderate cytotoxic activities toward the tested cell lines. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALTERNATIVE medicine
*ANTINEOPLASTIC agents
*BIOLOGICAL assay
*BIOLOGICAL models
*PHYSICAL & theoretical chemistry
*COLON tumors
*DOSE-effect relationship in pharmacology
*HEPATOCELLULAR carcinoma
*HIGH performance liquid chromatography
*LUNG tumors
*MEDICINAL plants
*NUCLEAR magnetic resonance spectroscopy
*OVARIAN tumors
*PROBABILITY theory
*RESEARCH funding
*SEEDS
*STOMACH tumors
*PLANT extracts
*DESCRIPTIVE statistics
*IN vitro studies
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 20
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 129998921
- Full Text :
- https://doi.org/10.1080/10286020.2017.1343822