感染性疾病内皮活化/功能障碍的生物标记物的研究进展.

Endothelial dysfunction plays an important role in the pathogenesis of multiple infectious diseases, such as sepsis,severe malaria and dengue hemorrhagic fever. Because endothelial activation usually precedes overt endothelial dysfunction, the corresponding endothelial biomarkers in serum or plasma can be detected earlier than those of the routine disease markers, and therefore,can be considered as parameters evaluating disease severity or prognosis of infectious diseases. In this review, the expression and clinical significance of endothelial cell functional mediators(angiopoietin-1 and angiopoietin-2) and soluble cell surface adhesion molecules(soluble E-selectin, sICAM-1 and sVCAM-1) is discussed in sepsis, malaria and dengue hemorrhagic fever. [ABSTRACT FROM AUTHOR]