Selective Diacetoxylation of Disubstituted 1,2,3-Triazoles through Palladium-Catalyzed C-H Activation.

A simple and efficient selective diacetoxylation of 1,4-disubstituted 1,2,3-triazoles by Pd-catalyzed C-H bond activation is described. PhI(OAc)2 was used as an acetyloxy source to convert aromatic sp2 C-H bonds into C-O bonds with high selectivity by employing a 1,2,3-triazole ring as an elegant directing group. A range of 1,2,3-triazoles bearing two acetyloxy groups can be readily synthesized by the reaction. [ABSTRACT FROM AUTHOR]