β-Adrenergic receptors and their interacting proteins

The three subtypes of β-adrenergic receptor (βAR) all interact with G proteins as a central aspect of their signaling. The various βAR subtypes also associate differentially with a variety of other cytoplasmic and transmembrane proteins. These βAR-interacting proteins play distinct roles in the regulation of receptor signaling and trafficking. The specificity of βAR associations with various binding partners can help to explain key physiological differences between βAR subtypes. Moreover, the differential tissue expression patterns of many of the βAR-interacting proteins may contribute to tissue-specific regulation of βAR function. [Copyright &y& Elsevier]