An in-based 3D metal-organic framework as heterogeneous Lewis acid catalyst for multi-component Strecker reactions.

A novel three-dimensional metal-organic framework (MOF) {[In 3 (NIPH) 3 (HNIPH)(OH) 2 ]·4H 2 O} n ( 1 ) (H 2 NIPH = 5-nitroisophthalic acid) with one-dimensional channels was synthesized and structurally characterized. Importantly, it demonstrates excellent catalytic activity for the Strecker reactions of two or three components under mild conditions. Moreover, the catalytic recycling of 1 as a representative example was explored. It can be easily separated and reused for no less than five runs with more than 80% conversion yield in catalytic ability. [ABSTRACT FROM AUTHOR]