Quantitating Toxaphene Parlar Congeners in Fish Using Large Volume Injection Isotope Dilution GC with Electron-Capture Negative Ion MS.

This article describes a novel automated ultratrace gas chromatography-mass spectrometry (GC-MS) method that quantitates the eight toxaphene Parlar congeners as designated in U.S. Environmental Protection Agency (EPA) Method 8276. This method was developed and applied to fish tissue and used a conventional sample preparation approach to extract, clean up, and fractionate selected Parlar congeners. Instrument detection limits for the eight toxaphene Parlar congeners quantitated were calculated in two ways. Quality control (QC) measures that were used to validate the new method are discussed and QC results are presented for these eight Parlar congeners of environmental significance. [ABSTRACT FROM AUTHOR]