Back to Search
Start Over
Associations of hyperglycemia and insulin resistance with biomarkers of endothelial dysfunction in Hispanic/Latino youths: Results from the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth).
- Source :
-
Journal of Diabetes & its Complications . May2017, Vol. 31 Issue 5, p836-842. 7p. - Publication Year :
- 2017
-
Abstract
- <bold>Aims: </bold>We hypothesized that Hispanic/Latino youth at high risk for diabetes would have elevated biomarkers of endothelial dysfunction.<bold>Methods: </bold>Among 1316 children 8-16years old from the Study of Latino Youth (SOL Youth), we used Poisson regression to obtain prevalence ratios (PRs) and 95% CIs for the cross-sectional association of quartiles of fasting glucose, HbA1c, and insulin resistance with E-selectin and plasminogen activator inhibitor-1 (PAI-1) levels above the median (≥48.1 and ≥2.02ng/mL, respectively).<bold>Results: </bold>Levels of E-selectin and PAI-1 were higher in children who were obese or had higher levels of hs-CRP (p<0.05). Insulin resistance was independently associated with higher levels of PAI-1 (adjusted PR and 95% CI for the highest versus lowest quartile (Q4 vs Q1): 2.25 [1.64, 3.09]). We found stronger evidence of associations of insulin resistance with higher levels of PAI-1 among boys as compared with girls (p-interaction = 0.10).<bold>Conclusions: </bold>Insulin resistance was associated with endothelial dysfunction, as measured by higher levels of PAI-1, in Hispanic/Latino youth. These biomarkers may be useful in risk stratification and prediction of diabetes and cardiovascular disease in high-risk youth. [ABSTRACT FROM AUTHOR]
- Subjects :
- *VASCULAR diseases
*CARDIOVASCULAR diseases
*COMPARATIVE studies
*DIABETIC angiopathies
*ENDOTHELIUM
*HISPANIC Americans
*HYPERGLYCEMIA
*INSULIN resistance
*LONGITUDINAL method
*RESEARCH methodology
*MEDICAL cooperation
*POISSON distribution
*PREDIABETIC state
*RESEARCH
*SURVEYS
*EVALUATION research
*RELATIVE medical risk
*DISEASE prevalence
*CROSS-sectional method
*DIABETIC cardiomyopathy
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 10568727
- Volume :
- 31
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Diabetes & its Complications
- Publication Type :
- Academic Journal
- Accession number :
- 129403418
- Full Text :
- https://doi.org/10.1016/j.jdiacomp.2017.01.019