Back to Search
Start Over
Synthesis and Evaluation of O³-Derived Diazeniumdiolates Activatable via Bioorthogonal Chemistry Reactions in Living Cells.
- Source :
-
Organic Letters . 4/20/2018, Vol. 20 Issue 8, p2164-2167. 4p. - Publication Year :
- 2018
-
Abstract
- A class of O²-alkyl derived diazeniumdiolates 3a-f and 4a-c were designed and synthesized as new bioorthogonal NO precursors, which can be effectively uncaged in the presence of a palladium catalyst via bioorthogonal bond cleavage reactions to generate NO in living cancer cells, eliciting potent antiproliferative activity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 20
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 129347735
- Full Text :
- https://doi.org/10.1021/acs.orglett.8b00423