Iron-Catalyzed Cross-Coupling of Primary and Secondary Alkyl Halides with Aryl Grignard Reagents.

The article focuses on the iron-catalyzed cross-coupling of primary and secondary alkyl halides with aryl Grignard reagents. It has been reported that iron catalysis allows to achieve cross-coupling between near stoichiometric amounts of an alkyl halide and an aryl Grignard reagent generally in excellent yield. The use of iron provides obvious practical and environmental merits, and the method allows the use of rather unreactive secondary bromides and chlorides on a synthetically useful scale. A useful feature of the present reaction is the compatibility of functional groups such as alkoxycarbonyl and N-indolyl group as well as alkenyl and alkynyl groups in the alkylating reagent survive under the reaction.