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KSHV induces immunoglobulin rearrangements in mature B lymphocytes.
- Source :
-
PLoS Pathogens . 4/16/2018, Vol. 14 Issue 4, p1-18. 18p. - Publication Year :
- 2018
-
Abstract
- Kaposi Sarcoma Herpesvirus (KSHV/HHV-8) is a B cell tropic human pathogen, which is present in vivo in monotypic immunoglobulin λ (Igλ) light chain but polyclonal B cells. In the current study, we use cell sorting to infect specific B cell lineages from human tonsil specimens in order to examine the immunophenotypic alterations associated with KSHV infection. We describe IL-6 dependent maturation of naïve B lymphocytes in response to KSHV infection and determine that the Igλ monotypic bias of KSHV infection in vivo is due to viral induction of BCR revision. Infection of immunoglobulin κ (Igκ) naïve B cells induces expression of Igλ and isotypic inclusion, with eventual loss of Igκ. We show that this phenotypic shift occurs via re-induction of Rag-mediated V(D)J recombination. These data explain the selective presence of KSHV in Igλ B cells in vivo and provide the first evidence that a human pathogen can manipulate the molecular mechanisms responsible for immunoglobulin diversity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IMMUNOGLOBULINS
*LYMPHOCYTES
*B cells
*GENE expression
*IMMUNE response
Subjects
Details
- Language :
- English
- ISSN :
- 15537366
- Volume :
- 14
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- PLoS Pathogens
- Publication Type :
- Academic Journal
- Accession number :
- 129083479
- Full Text :
- https://doi.org/10.1371/journal.ppat.1006967