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Copper induces structural changes in N-terminus of human prion protein.
- Source :
-
Biochemical & Biophysical Research Communications . May2018, Vol. 499 Issue 3, p470-474. 5p. - Publication Year :
- 2018
-
Abstract
- Copper ions reportedly bind to the cellular prion (PrP C ) and induce PrP proteinase K (PK) resistant from (PrP res ). PrP C also plays a role in response to oxidative stress. By using purified human PrP23-98 containing octarepeats, we have found that Cu(II) induces PrP res determined by Western blots and atomic force microscopy, and structural changes detected by hydrogen/deuterium exchange in the PrP N-terminus. Therefore, we have provided the evidence that copper ions play an important role in the change of N-terminus of human prion protein. [ABSTRACT FROM AUTHOR]
- Subjects :
- *N-terminal residues
*COPPER ions
*PRIONS
*PROTEIN binding
*OXIDATIVE stress
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 499
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 129048339
- Full Text :
- https://doi.org/10.1016/j.bbrc.2018.03.171