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Association between the <italic>PPP1R3B</italic> polymorphisms and serum lipid traits, the risk of coronary artery disease and ischemic stroke in a southern Chinese Han population.
- Source :
-
Nutrition & Metabolism . 4/12/2018, Vol. 15 Issue 1, pN.PAG-N.PAG. 1p. 1 Diagram, 5 Charts. - Publication Year :
- 2018
-
Abstract
- Background: Little is known about the association of the protein phosphatase 1 regulatory subunit 3B gene (<italic>PPP1R3B</italic>) single nucleotide polymorphisms (SNPs) and serum lipid levels, the risk of coronary artery disease (CAD) and ischemic stroke (IS) in the Chinese populations. This study detected such association in a Southern Chinese Han population. Methods: Genotypes of 4 novel <italic>PPP1R3B</italic> SNPs (rs12785, rs330910, rs330915 and rs9949) in 1704 Han Chinese (CAD, 556; IS, 531 and control, 617) were determined by the Snapshot technology. Results: The rs12785A and rs9949A allele frequency was higher in both CAD/IS patients than in controls. The rs330910T and rs330915T allele frequency was also higher in CAD patients than in controls. The rs330910T allele carriers in controls had lower serum low-density lipoprotein cholesterol (LDL-C) levels than the rs330910T allele non-carriers (<italic>P</italic> < 0.0014). The rs12785A, rs9949A and rs330910T allele carriers were associated with an increased risk of CAD (<italic>P</italic> = 0.008–0.004). There was strong linkage disequilibrium among the 4 SNPs in the controls and CAD/IS patients. The T-A-A-G haplotype was associated with a decreased risk of CAD and IS, whereas the A-A-T-A haplotype was associated with an increased risk for IS. Haplotype-environment interactions on the risk of CAD and IS were also observed. Conclusions: Several <italic>PPP1R3B</italic> polymorphisms were associated with serum LDL-C levels, the risk of CAD and IS in the Southern Chinese Han population. But these findings still need to be confirmed in the other populations with larger sample sizes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17437075
- Volume :
- 15
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Nutrition & Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 129028008
- Full Text :
- https://doi.org/10.1186/s12986-018-0266-y