Pancreas transplantation from marginal donors

: BackgroundMarginal donor organs are a supplementary source of grafts that has not been fully exploited for pancreas transplantation (PTx).: MethodsA total of 100 PTx were performed with grafts procured from either 48 nonmarginal donors (NMD) or 52 marginal donors (MD), namely age greater than 45 years and/or severe hemodynamic instability at the time of procurement. PTx outcome was evaluated as the incidence of delayed endocrine pancreas function (DEPF), the complication rate, and the patient and graft survivals.: ResultsThe DEPF rate was 6.2% for NMD as compared to 0 for MD (P > .05). Relaparotomy rate was 12.5% for NMD and 9.6% for MD (P > .05). Actuarial 1-year graft survival was 91.7% and 94.2% for NMD and MD, respectively (P > .05). Equivalent figures for patients were 97.9% and 98.1%, respectively (P > .05).: ConclusionsPancreas from MD may be safely employed and significantly expand the donor pool for PTx. [Copyright &y& Elsevier]