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IL-6 blockade in systemic juvenile idiopathic arthritis – achievement of inactive disease and remission (data from the German AID-registry).
- Source :
-
Pediatric Rheumatology . 4/5/2018, Vol. 16, p1-1. 1p. - Publication Year :
- 2018
-
Abstract
- Background: Systemic juvenile idiopathic arthritis (sJIA) is a complex disease with an autoinflammatory component of unknown etiology related to the innate immune system. A major role in the pathogenesis has been ascribed to proinflammatory cytokines like interleukin-6 (IL-6), and effective drugs inhibiting their signaling are being developed. This study evaluates sJIA patients treated with the IL-6 inhibitor tocilizumab (TCZ) concerning clinical response rate, disease course and adverse effects in a real-life clinical setting. Methods: In 2009 a clinical and research consortium was established, including an online registry for autoinflammatory diseases (AID) (<ext-link>https://aid-register.de</ext-link>). Data for this retrospective TCZ study were documented by 13 centers. Results: From 7/2009 to 4/2014, 200 patients with sJIA were recorded in the AID-registry. Out of these, 46 (19 m, 27 f, age 1–18 years) received therapy with TCZ. Long term treatment (median 23 months) has been documented in 24/46 patients who were evaluated according to Wallace criteria (active disease 6/24, inactive disease 5/24, remission 13/24 cases). Under observation co-medication were used in 40/46 cases. Adverse events were reported in 11/46 patients. The clinical response rate (no clinical manifestation, no increased inflammation parameters) within the first 12 weeks of treatment was calculated to be 35%. Conclusion: Out of 200 sJIA children reported in the German AID-registry, 46 were treated with TCZ, showing a clinical response rate of 35% during the first 12 weeks, and inactive disease and/or remission under medication in 75% after one year. Adverse events were seen in 24% and severe adverse events in 4%. Trial registration: The AID-Registry is funded by the BMBF (01GM08104, 01GM1112D, 01GM1512D). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15460096
- Volume :
- 16
- Database :
- Academic Search Index
- Journal :
- Pediatric Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 128896608
- Full Text :
- https://doi.org/10.1186/s12969-018-0236-y