75例含果糖制剂致不良反应.

OBJECTIVE:To probe into the possible factors of adverse drug reactions ( ADR) induced by fructose preparations , so as to provide reference for the rational drug use in clinic .METHODS:By retrospective investigation method, 75 cases of ADR induced by fructose preparations collected in Zhongshan from Jan .2008 to Jul.2015 were statistically analyzed.RESULTS:Of the 75 cases of ADR, females were 49 cases(65.33%), which distributed in all ages.The number of cases with ADR after first administration of 30 min took the lead, were 52 cases(69.33%);and the drug combination were 36 cases ( 48.00%) .The main clinical symptoms of ADR were rash , itching and other allergic reactions as well as chills , fever and other systemic damage .CONCLUSIONS: The clinic should take the effects of organic factors like the factors of drugs , patients'age and gender , and medication factors like drug combination , medication time on ADR induced by fructose preparations into consideration , prescribe medication in strict accordance with the indications and avoid unnecessary compatible use , so as to ensure the medication safety . [ABSTRACT FROM AUTHOR]