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Effects of warmed carrier fluid on nefopam injection-induced pain.
- Source :
-
Korean Journal of Pain . Apr2018, Vol. 31 Issue 2, p102-108. 7p. - Publication Year :
- 2018
-
Abstract
- Background: Nefopam is a non-opioid, non-steroidal analgesic drug with fewer adverse effects than narcotic analgesics and nonsteroidal anti-inflammatory drugs, and is widely used for postoperative pain control. Because nefopam sometimes causes side effects such as nausea, vomiting, somnolence, hyperhidrosis and injection-related pain, manufacturers are advised to infuse it slowly, over a duration of 15 minutes. Nevertheless, pain at the injection site is very common. Therefore, we investigated the effect of warmed carrier fluid on nefopam injection-induced pain. Methods: A total of 48 patients were randomly selected and allocated to either a control or a warming group. Warming was performed by diluting 40 mg of nefopam in 100 ml of normal saline heated to 31-32°C using two fluid warmers. The control group was administered 40 mg of nefopam dissolved in 100 ml of normal saline stored at room temperature (21-22°C) through the fluid warmers, but the fluid warmers were not activated. Results: The pain intensity was lower in the warming group than in the control group (P < 0.001). The pain severity and tolerance measurements also showed statistically significant differences between groups (P < 0.001). In the analysis of vital signs before and after the injection, the mean blood pressure after the injection differed significantly between the groups (P = 0.005), but the heart rate did not. The incidence of hypertension also showed a significant difference between groups (P = 0.017). Conclusions: Use of warmed carrier fluid for nefopam injection decreased injection-induced pain compared to mildly cool carrier fluid. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NARCOTIC antagonists
*POSTOPERATIVE pain
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 20059159
- Volume :
- 31
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Korean Journal of Pain
- Publication Type :
- Academic Journal
- Accession number :
- 128873262
- Full Text :
- https://doi.org/10.3344/kjp.2018.31.2.102