Gleason grade after hormonal therapy may be invalid.

Discusses findings of the Prostate Cancer Prevention Trial which showed that the use of finasteride or Proscar reduced the biopsy prevalence of prostate cancer compared with placebo. Percentage of cancer reduction in patients receiving the drug; Effects of Gleason grading performed after 5-alpha-reductase inhibitor or other other hormonal therapy; Histologic changes occurring from all forms of androgen deprivation therapy.