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Mechanistic investigation of imine formation in ruthenium‐catalyzed N‐alkylation of amines with alcohols.
- Source :
-
Applied Organometallic Chemistry . Apr2018, Vol. 32 Issue 4, p1-1. 7p. - Publication Year :
- 2018
-
Abstract
- Imines are observed frequently in ruthenium‐catalyzed N‐alkylation of amines with alcohols. Herein, nitrogen–phosphine functionalized carbene ligands were developed and used in ruthenium‐catalyzed N‐alkylation to explore the mechanism of imine formation. The results showed that strongly electron‐donating ligands were beneficial for imine formation and alcohol dehydrogenation to generate acid. In addition, with an increase of electron density of nitrogen atom in substituted amines, the yield of imines in N‐alkylation was improved. At the same time, with electron‐rich imines as substrates, the transfer hydrogenation of imines became difficult. It is suggested that strongly electron‐donating ligands and substrates caused an increase of electron density on the ruthenium center, which resulted in the elimination of hydrogen atoms in active species [LRuH2] as hydrogen gas rather than transfer onto the imine coordinated with the ruthenium center. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02682605
- Volume :
- 32
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Applied Organometallic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 128817654
- Full Text :
- https://doi.org/10.1002/aoc.4277