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Nickel‐Catalyzed Umpolung Arylation of Ambiphilic α‐Bromoalkyl Boronic Esters.

Authors :
Sun, Shang‐Zheng
Martin, Ruben
Source :
Angewandte Chemie. 3/26/2018, Vol. 130 Issue 14, p3684-3687. 4p.
Publication Year :
2018

Abstract

Abstract: A nickel‐catalyzed reductive arylation of ambiphilic α‐bromoalkyl boronic esters with aryl halides is described. This platform provides an unrecognized opportunity to promote the catalytic umpolung reactivity of ambiphilic reagents with aryl halides, thus unlocking a new cross‐coupling strategy that complements existing methods for the preparation of densely functionalized alkyl‐substituted organometallic reagents from simple and readily accessible precursors. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00448249
Volume :
130
Issue :
14
Database :
Academic Search Index
Journal :
Angewandte Chemie
Publication Type :
Academic Journal
Accession number :
128732541
Full Text :
https://doi.org/10.1002/ange.201712428