Isolation, Synthesis, and Biological Activity of Quindoline, a Valuable Indoloquinoline Natural Product and Useful Key Intermediate.

Quindoline is one of the simplest naturally occurring monomeric indoloquinoline alkaloids. Chemists exhibited interest in this compound before it was isolated from a natural source. The different approaches toward the total synthesis of the natural product and its performance in various biological tests are discussed. Aspects related to the isolation of quindoline from different ethnomedicinally relevant plants around the world are also reviewed. 1 Introduction 2 Isolation and Biogenetic Considerations 3 Total Syntheses of Quindoline 3.1 Early Synthetic Studies 3.2 Syntheses from Benzenoids 3.3 Syntheses from Indoles 3.4 Syntheses from Quinolines 4 Biological Activity Studies 5 Conclusions. [ABSTRACT FROM AUTHOR]