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PET Imaging on Dynamic Metabolic Changes after Combination Therapy of Paclitaxel and the Traditional Chinese Medicine in Breast Cancer-Bearing Mice.
- Source :
-
Molecular Imaging & Biology . Apr2018, Vol. 20 Issue 2, p309-317. 9p. - Publication Year :
- 2018
-
Abstract
- <bold>Purpose: </bold>The aim of the study was to non-invasively evaluate the anticancer activity of a traditional Chinese medicine-Huaier, combined with paclitaxel (PTX) in breast cancer bearing mice by detecting dynamic metabolic changes with positron emission tomography (PET).<bold>Procedures: </bold>Balb/c nude mice were randomly divided into one of the four groups: Huaier, PTX, PTX + Huaier, or the control. PET imaging with 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) was performed to monitor the metabolic changes in BT474 (luminal B) and MDA-MB-231 (triple-negative) breast cancer xenografts. Immunohistochemistry (IHC) study was performed immediately after the final PET scan to assess the expressions of phosphatidylinositol 3-kinase (PI3K), phospho-AKT (p-AKT), caspase-3, and vascular endothelial growth factor (VEGF).<bold>Results: </bold>Compared to the control group, [18F]FDG accumulation demonstrated a significant decrease in PTX + Huaier (p < 0.01) or Huaier group (p < 0.05), which was consistent to the decreased expression of PI3K (p < 0.05) and p-AKT (p < 0.05) in the breast cancer xenografts.<bold>Conclusion: </bold>The therapeutic effect of Huaier combined with PTX was superior than the PTX alone in BT474 and MDA-MB-231 breast cancer-bearing mice. [18F]FDG PET imaging could be a potential non-invasive approach to assess the metabolic changes after chemotherapy combined with traditional Chinese medicine in the breast cancer. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BREAST cancer treatment
*PACLITAXEL
*CHINESE medicine
*CELL metabolism
*POSITRON emission tomography
*CANCER tomography
*COMBINATION drug therapy
*LABORATORY mice
*ANIMAL experimentation
*ANTINEOPLASTIC agents
*BREAST tumors
*CELL lines
*CELL physiology
*COMPARATIVE studies
*DEOXY sugars
*RESEARCH methodology
*MEDICAL cooperation
*MICE
*RADIOPHARMACEUTICALS
*RESEARCH
*EVALUATION research
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 15361632
- Volume :
- 20
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Molecular Imaging & Biology
- Publication Type :
- Academic Journal
- Accession number :
- 128617542
- Full Text :
- https://doi.org/10.1007/s11307-017-1108-4