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Proanthocyanidins against Oxidative Stress: From Molecular Mechanisms to Clinical Applications.
- Source :
-
BioMed Research International . 3/12/2018, Vol. 2018, p1-11. 11p. - Publication Year :
- 2018
-
Abstract
- Proanthocyanidins (PCs) are naturally occurring polyphenolic compounds abundant in many vegetables, plant skins (rind/bark), seeds, flowers, fruits, and nuts. Numerous<italic> in vitro</italic> and<italic> in vivo</italic> studies have demonstrated myriad effects potentially beneficial to human health, such as antioxidation, anti-inflammation, immunomodulation, DNA repair, and antitumor activity. Accumulation of prooxidants such as reactive oxygen species (ROS) exceeding cellular antioxidant capacity results in oxidative stress (OS), which can damage macromolecules (DNA, lipids, and proteins), organelles (membranes and mitochondria), and whole tissues. OS is implicated in the pathogenesis and exacerbation of many cardiovascular, neurodegenerative, dermatological, and metabolic diseases, both through direct molecular damage and secondary activation of stress-associated signaling pathways. PCs are promising natural agents to safely prevent acute damage and control chronic diseases at relatively low cost. In this review, we summarize the molecules and signaling pathways involved in OS and the corresponding therapeutic mechanisms of PCs. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CARDIOVASCULAR disease prevention
*PREVENTION of chronic diseases
*SKIN disease prevention
*NEURODEGENERATION
*METABOLIC disorders
*DNA
*REACTIVE oxygen species
*ANTI-inflammatory agents
*ANTINEOPLASTIC agents
*ANTIOXIDANTS
*CELLULAR signal transduction
*HEALTH
*POLYPHENOLS
*PHYTOCHEMICALS
*OXIDATIVE stress
*PREVENTION
*PHYSIOLOGY
IMMUNE system physiology
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Volume :
- 2018
- Database :
- Academic Search Index
- Journal :
- BioMed Research International
- Publication Type :
- Academic Journal
- Accession number :
- 128487683
- Full Text :
- https://doi.org/10.1155/2018/8584136