1<italic>H</italic>‐1,2,3‐Triazole‐tethered Isatin–coumarin Hybrids: Design, Synthesis and <italic>In Vitro</italic> Anti‐mycobacterial Evaluation.

A series of novel 1H‐1,2,3‐triazole‐tethered isatin–coumarin hybrids <bold>7a</bold>–<bold>l</bold> integrate three anti‐tuberculosis bioactive substances/pharmacophoric units including coumarin, isatin, and <bold>I</bold>‐<bold>A09</bold> were designed, synthesized, and tested for their in vitro anti‐mycobacterial activity against Mycobacterium smegmatis and Mycobacterium tuberculosis H37Rv as well as cytotoxicity in VERO cell line. The results showed that all hybrids exhibited weak to moderate activity against the tested two strains with minimum inhibitory concentration ranging from 50 to 200 μg/mL. [ABSTRACT FROM AUTHOR]