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Self-Assembly of Telechelic Tyrosine End-Capped PEO Star Polymers in Aqueous Solution.
- Source :
-
Biomacromolecules . Jan2018, Vol. 19 Issue 1, p167-177. 11p. - Publication Year :
- 2018
-
Abstract
- We investigate the self-assembly of two telechelic star polymer-peptide conjugates based on poly(ethylene oxide) (PEO) four-arm star polymers capped with oligotyrosine. The conjugates were prepared via N-carboxy anhydride-mediated ring-opening polymerization from PEO star polymer macroinitiators. Self-assembly occurs above a critical aggregation concentration determined via fluorescence probe assays. Peptide conformation was examined using circular dichroism spectroscopy. The structure of self-assembled aggregates was probed using small-angle X-ray scattering and cryogenic transmission electron microscopy. In contrast to previous studies on linear telechelic PEO-oligotyrosine conjugates that show self-assembly into β-sheet fibrils, the star architecture suppresses fibril formation and micelles are generally observed instead, a small population of fibrils only being observed upon pH adjustment. Hydrogelation is also suppressed by the polymer star architecture. These peptide-functionalized star polymer solutions are cytocompatible at sufficiently low concentration. These systems present tyrosine at high density and may be useful in the development of future enzyme or pH-responsive biomaterials. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TYROSINE
*TELECHELIC polymers
*AQUEOUS solutions
*CIRCULAR dichroism
*MICELLES
Subjects
Details
- Language :
- English
- ISSN :
- 15257797
- Volume :
- 19
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Biomacromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 128467846
- Full Text :
- https://doi.org/10.1021/acs.biomac.7b01420