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DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia.
- Source :
-
Clinical Epigenetics . 3/5/2018, Vol. 10, p1-1. 1p. - Publication Year :
- 2018
-
Abstract
- Background: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients. Methods: Six hundred and one BCP-ALL samples from Nordic pediatric patients (age 1–18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data. Results: Among the 137 patients that later relapsed, patients with a CIMP− profile (<italic>n</italic> = 42) at initial diagnosis had an inferior overall survival (pOS5years 33%) compared to CIMP+ patients (<italic>n</italic> = 95, pOS5years 65%) (<italic>p</italic> = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors. Conclusion: CIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DNA methylation
*LYMPHOBLASTIC leukemia
*BIOMARKERS
Subjects
Details
- Language :
- English
- ISSN :
- 18687075
- Volume :
- 10
- Database :
- Academic Search Index
- Journal :
- Clinical Epigenetics
- Publication Type :
- Academic Journal
- Accession number :
- 128324199
- Full Text :
- https://doi.org/10.1186/s13148-018-0466-3