Dynamics of regeneration of striated muscles in rats with posttraumatic reflex contractures.

In the comparative aspect the regeneration processes of striated muscles of hind left leg were researched in rats with posttraumatic reflex contractures against the background of physiotherapeutic treatment. Macroscopic and microscopic evaluation of pathomorphological changes has been conducted in this work. A relative area of myogenic elements (striated muscle elements), connective-tissue elements and neovasculature in the muscular-connective tissue in the scar in percentage has been determined using the method of point counting (field method). Depending on the signs of pain behavior (behavioral changes, additional signs), the intensity of myogenic pain syndrome (low, moderate, high, very high) has been studied. It has been established that the use of magnetic-laser therapy led to the formation of muscular-connective tissue scar up to the 28th day with a predominance of a portion of striated muscle tissue of 90.74±0.17%. Behavioral and motor responses became normalized; no pain was observed in 56% of rats, pain intensity was low in 44%. In animals with the same trauma that were not treated, the portion of striated muscle tissue was 37.08±0.34%, and signs of pain of high and moderate intensity were observed. By the 28th day, the animals could brace against their hind limbs while moving, but due to a sharp restriction of the function of the left hind limb, they could not move freely. The obtained results are the basis for developing new approaches to improving the methods of remedial treatment of contractures using magnetic-laser therapy. [ABSTRACT FROM AUTHOR]