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Post-ERCP Bleeding in the Era of Multiple Antiplatelet Agents.
- Source :
-
Gut & Liver . Mar2018, Vol. 12 Issue 2, p214-218. 5p. - Publication Year :
- 2018
-
Abstract
- Background/Aims: This study aimed to determine the risk of post-endoscopic retrograde cholangiopancreatography (post-ERCP) bleeding among patients taking antiplatelet agents (APAs), particularly in the era of multiple APAs. Methods: The primary outcomes were the frequency, type, and severity of ERCP-related bleeding according to the use of APAs. Results: The frequencies of post-ERCP bleeding among the four different groups were 16 of 2,083 (0.8%) in the no drug group, 12 of 256 (4.7%) in the aspirin group, 3 of 48 (6.3%) in the single APA group, and 4 of 48 (8.3%) in the multiple APA group (p<0.001). In the univariate analysis, post-ERCP bleeding was associated with age, pull-type sphincterotomy, and APA and was inversely associated with balloon dilation of the biliary orifice. In the multivariate analysis, pull-type sphincterotomy (odds ratio [OR], 7.829; 95% confidence interval [CI], 1.411 to 43.453; p=0.019) and country (Korea: OR, 0.124; 95% CI, 0.042 to 0.361; p<0.001) were associated with post-ERCP bleeding. Conclusions: The frequency of post-ERCP bleeding was statistically higher in patients on any APA within 6 days prior to ERCP. However, in the multivariate analysis, APA use was not associated with post-ERCP bleeding. Until a large, adequately powered study to detect differences is performed, caution is recommended when considering invasive procedures during ERCP in patients on APAs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19762283
- Volume :
- 12
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Gut & Liver
- Publication Type :
- Academic Journal
- Accession number :
- 128293035
- Full Text :
- https://doi.org/10.5009/gnl17204