Back to Search
Start Over
Anti-Zn2+-Toxicity of 4-Hydroxybenzyl Alcohol in Astrocytes and Neurons Contribute to a Robust Neuroprotective Effects in the Postischemic Brain.
- Source :
-
Cellular & Molecular Neurobiology . Apr2018, Vol. 38 Issue 3, p615-626. 12p. - Publication Year :
- 2018
-
Abstract
- 4-Hydroxybenzyl alcohol (4-HBA) is an important phenolic constituent of <italic>Gastrodia elata</italic> (GE) Blume, which is used as a traditional herbal medicine in East Asia. Many activities have been reported to underlie the beneficial effects of 4-HBA in brain, such as, anti-oxidative, anti-inflammatory, anti-excitotoxic, and anti-apoptotic effects in neurons and microglia. Here, the authors demonstrate the robust neuroprotective effects of 4-HBA in rat middle cerebral artery occlusion (MCAO) model of stroke, and showed anti-Zn2+ toxicity in neurons and astrocytes as a molecular mechanism contributing to these effects. Intraperitoneal administration of 4-HBA (20 mg/kg) in Sprague-Dawley rats 1 h after MCAO reduced infarct volumes to 27.1 ± 9.2% of that of MCAO controls and significantly ameliorated motor impairments and neurological deficits. Significant suppressions of Zn2+-induced cell death, ROS generation, and PARP-1 induction by 4-HBA were observed in primary cortical cultures. 4-HBA also protected astrocytes from Zn2+-induced toxicity and suppressing ROS generation by employing slightly different molecular mechanisms, i.e., suppressing PARP-1 induction and NAD depletion under acute Zn2+-treatment and suppressing p67 NADPH oxidase subunit induction under chronic Zn2+-treatment. Results indicate that the protective effects of 4-HBA against Zn2+-toxicity in neurons and astrocytes contribute to its robust neuroprotective effects in the postischemic brain. Considering the pleiotropic effects of 4-HBA, which have been reported in previous reports and added in the present study, it has therapeutic potential for the amelioration of ischemic brain damage. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PHENOL
*ALCOHOLS (Chemical class)
*ASTROCYTES
*NEURONS
*ANTERIOR cerebral artery
Subjects
Details
- Language :
- English
- ISSN :
- 02724340
- Volume :
- 38
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Cellular & Molecular Neurobiology
- Publication Type :
- Academic Journal
- Accession number :
- 128291861
- Full Text :
- https://doi.org/10.1007/s10571-017-0508-y