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Long noncoding RNAs in cancer cells.
- Source :
-
Cancer Letters . Apr2018, Vol. 419, p152-166. 15p. - Publication Year :
- 2018
-
Abstract
- Long noncoding RNA (lncRNA) has recently been investigated as key modulators that regulate many biological processes in human cancers via diverse mechanisms. LncRNAs can interact with macromolecules such as DNA, RNA, or protein to exert cellular effects and to act as either tumor promoters or tumor suppressors in various malignancies. Moreover, the aberrant expression of lncRNAs may be detected in multiple cancer phenotypes by employing the rapidly developing modern gene chip technology and bioinformatics analysis. Herein, we highlight the mechanisms of action of lncRNAs, their functional cellular roles and their involvement in cancer progression. Finally, we provide an overview of recent progress in the lncRNA field and future potential for lncRNAs as cancer diagnostic markers and therapeutics. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NON-coding RNA
*CANCER
*MACROMOLECULES
*TUMOR suppressor genes
*CANCER invasiveness
*CANCER diagnosis
*CANCER treatment
*TUMOR treatment
*BIOLOGICAL models
*COMPARATIVE studies
*DISEASE susceptibility
*GENES
*RESEARCH methodology
*MEDICAL cooperation
*GENETIC mutation
*RESEARCH
*RNA
*TUMORS
*EVALUATION research
*DISEASE progression
Subjects
Details
- Language :
- English
- ISSN :
- 03043835
- Volume :
- 419
- Database :
- Academic Search Index
- Journal :
- Cancer Letters
- Publication Type :
- Academic Journal
- Accession number :
- 128198368
- Full Text :
- https://doi.org/10.1016/j.canlet.2018.01.053