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RuII-Carbonyl photoCORMs with N,N-Benzimidazole Bidentate Ligands: Spectroscopic, Lysozyme Binding Affinity, and Biological Activity Evaluation.
- Source :
-
European Journal of Inorganic Chemistry . Feb2018, Vol. 2018 Issue 7, p852-860. 9p. - Publication Year :
- 2018
-
Abstract
- The photoinduced carbon monoxide releasing properties of pyridylbenzimidazole-based RuII-carbonyl complexes functionalized with alkylated sulfonate (LSO3H), phthalimide (LPhth), and morpholine (Lmorph) moieties, [RuCl(CO)3LSO3H]Cl (1) and [RuCl2(CO)2L] {where L = LPhth (2) and Lmorph (3)}, are reported. The geometrical stereochemistry and electronic transitions are assigned with the aid of DFT and TDDFT calculations. The compounds are evaluated for potential antimicrobial and cytotoxic active properties [against noncancerous human embryonic kidney cells (HEK293)]. Complex 2 shows interesting antifungal activity towards Candida albicans and Cryptococcus neoformans, with a similar MIC value of 24 nM. Metalation of hen egg-white lysozyme (HEWL), as a biocompatible carrier, is studied in the dark and upon exposure to light. Stable protein adducts, capable of release CO upon illumination, are formed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *METAL complexes
*BENZIMIDAZOLES
*RUTHENIUM compounds
*LYSOZYMES
*CARBON monoxide
Subjects
Details
- Language :
- English
- ISSN :
- 14341948
- Volume :
- 2018
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- European Journal of Inorganic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 128191181
- Full Text :
- https://doi.org/10.1002/ejic.201701341