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Beta-2-glycoprotein-1 and alpha-1-antitrypsin as urinary markers of renal cancer in von Hippel–Lindau patients.
- Source :
-
Biomarkers . Mar2018, Vol. 23 Issue 2, p123-130. 8p. - Publication Year :
- 2018
-
Abstract
- Context:Von Hippel–Lindau disease (VHLD) is a rare inherited neoplastic syndrome. Among all the VHLD-associated tumors, clear cell renal cell carcinoma (ccRCC) is the major cause of death. Objective:The aim of this paper is the discovery of new non-invasive biomarker for the monitoring of VHLD patients. Materials and methods:We compared the urinary proteome of VHLD patients, ccRCC patients and healthy volunteers. Results:Among all differentially expressed proteins, alpha-1-antitrypsin (A1AT) and APOH (beta-2-glycoprotein-1) are strongly over-abundant only in the urine of VHLD patients with a history of ccRCC. Discussion and conclusion:A1AT and APOH could be promising non-invasive biomarkers. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 1354750X
- Volume :
- 23
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Biomarkers
- Publication Type :
- Academic Journal
- Accession number :
- 128182585
- Full Text :
- https://doi.org/10.1080/1354750X.2016.1269132