Back to Search
Start Over
Synthesis of-4-((4-trimethylsilyl-1 H -1,2,3-triazol-1-yl)methyl)-2 H -chromen-2-ones: A novel class of heteroaryl anionic synthon.
- Source :
-
Synthetic Communications . 2018, Vol. 48 Issue 5, p588-593. 6p. 4 Diagrams, 1 Chart. - Publication Year :
- 2018
-
Abstract
- A one-pot synthesis of some novel anionic scaffolds: the substituted-4-((4-trimethylsilyl-1H-1,2,3-triazol-1-yl)methyl)-2H-chromen-2-one is reported. Reaction of 10 different substituted bromomethylcoumarins with trimethylsilylacetylene and sodium azide in the presence of copper(I) iodide catalyst gave the corresponding heteroaryl conjugates: the substituted-4-((4-trimethylsilyl-1H-1,2,3-triazol-1-yl)methyl)-2H-chromen-2-one in 70–92% yields. The structures of the synthesized compounds have been completely characterized by spectral and elemental analyses. For the first time, the representative single-crystal X-ray structure analysis of 6-methoxy-4-((4-trimethylsilyl-1H-1,2,3-triazol-1-yl)methyl)-2H-chromen-2-one is reported which confirms the formation of anionic synthon which bears the trimethylsilyl-group. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHEMICAL synthesis
*TRIAZOLES
*COUMARINS
*CUPROUS iodide
*SODIUM azide
Subjects
Details
- Language :
- English
- ISSN :
- 00397911
- Volume :
- 48
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Synthetic Communications
- Publication Type :
- Academic Journal
- Accession number :
- 128182091
- Full Text :
- https://doi.org/10.1080/00397911.2017.1416634