Epigenetické změny jako nový nástroj pro prognostickou stratifikaci pacientů s chronickou lymfocytární leukemií.

Chronic lymphocytic leukaemia (CLL) is a clonal B lymphocyte malignancy with a highly heterogeneous course. Some patients remain asymptomatic and do not require treatment for many years, while patients with aggressive forms of the disease require therapy soon after diagnosis. Recently, evidence has been growing about the important role of methylations in natural evolution as well as in the development of various diseases including cancer. Whole genome sequencing has revealed that in CLL, similarly to other malignancies, aberrant methylations arise in the early phases of the disease. CLL patients have diverse methylation profiles and the methylation status of certain loci correlates with disease aggressiveness. In this brief report, we focus on methylation changes and their role in CLL prognosis.. [ABSTRACT FROM AUTHOR]