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Analgesic and Anti-Inflammatory Effects of 80% Methanol Extract of Leonotis ocymifolia (Burm.f.) Iwarsson Leaves in Rodent Models.
- Source :
-
Evidence-based Complementary & Alternative Medicine (eCAM) . 2/20/2018, Vol. 2018, p1-8. 8p. 4 Graphs. - Publication Year :
- 2018
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Abstract
- <italic>Background</italic>. Pain and inflammation are the major health problems commonly treated with traditional remedies mainly using medicinal plants.<italic> Leonotis ocymifolia</italic> is one of such medicinal plants used in folkloric medicine of Ethiopia. However, the plant has not been scientifically evaluated. The aim of this study was to evaluate analgesic and anti-inflammatory effects of the 80% methanol leaves extract of<italic> Leonotis ocymifolia</italic> using rodent models.<italic> Method</italic>. The central and peripheral analgesic effect of the extract at 100, 200, and 400 mg/kg dose levels was evaluated using hot plate and acetic acid induced writhing rodent models, whereas carrageenan induced paw edema and cotton pellet granuloma methods were used to screen anti-inflammatory effect of the extract at the same dose levels. Acute toxicity test was also done. Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test and p<0.05 was considered significant.<italic> Results</italic>. The extract did not produce mortality up to 2000 mg/kg. All tested doses of the extract showed significant analgesic effect with maximum latency response of 62.8% and inhibition of acetic acid induced writhing. Maximum anti-inflammatory effect was recorded at 6 h after induction, with 75.88% reduction in carrageenan induced paw edema. Moreover, all tested doses of extract significantly inhibited the formation of inflammatory exudates and granuloma formation (p<0.001).<italic> Conclusion</italic>. The study indicated that the extract was safe in mice and it has both analgesic and anti-inflammatory effect in rodent models. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ACETIC acid
*ANIMAL experimentation
*DRUG design
*DOSE-effect relationship in pharmacology
*CLINICAL drug trials
*EDEMA
*GRANULOMA
*INFLAMMATORY mediators
*LEAVES
*MEDICINAL plants
*METHANOL
*MICE
*PAIN
*POLYSACCHARIDES
*PROBABILITY theory
*STATISTICS
*TOXICITY testing
*PLANT extracts
*DATA analysis
*ONE-way analysis of variance
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Volume :
- 2018
- Database :
- Academic Search Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 128093615
- Full Text :
- https://doi.org/10.1155/2018/1614793