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Long-term outcomes in cancer patients who did or did not pursue fertility preservation.
- Source :
-
Fertility & Sterility . Feb2018, Vol. 109 Issue 2, p349-355. 7p. - Publication Year :
- 2018
-
Abstract
- <bold>Objective: </bold>To compare long-term outcomes of cancer patients who pursued fertility preservation (FP) with those who did not and compare random-start (RS) and menstrual cycle-specific (CS) protocols for FP.<bold>Design: </bold>Retrospective cohort.<bold>Setting: </bold>Single urban academic institution.<bold>Patient(s): </bold>Oncology patients who contacted the FP patient navigator, 2005-2015.<bold>Intervention(s): </bold>None.<bold>Main Outcome Measure(s): </bold>Time to cancer treatment, disease-free survival, and reproductive outcomes in FP versus no-FP patients and cycle outcomes for RS versus CS protocols. Data were analyzed by χ2 and logistic regression.<bold>Result(s): </bold>Of 497 patients who met the inclusion criteria, 41% elected FP. The median number of days to cancer treatment was 33 and 19 days in the FP and no-FP groups, respectively. There was no difference in cancer recurrence or mortality. There were no differences in stimulation parameters, outcomes, or days to next cancer treatment in RS versus CS protocols. Twenty-one patients returned to use cryopreserved specimens, resulting in 16 live births. Eight of 21 returning patients used a gestational carrier. Thirteen FP (6.4%) and 16 no-FP (5.5%) patients experienced a spontaneous pregnancy.<bold>Conclusion(s): </bold>FP is both safe and efficacious for eligible cancer patients. Only 10% of patients returned to use cryopreserved specimens, and almost half used a gestational carrier, suggesting the need for further research into reproductive decision-making in cancer survivors. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00150282
- Volume :
- 109
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Fertility & Sterility
- Publication Type :
- Academic Journal
- Accession number :
- 127981003
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2017.10.029