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Artificial cryopreserved embryo transfer cycle success depends on blastocyst developmental rate and progesterone timing.
- Source :
-
Reproductive BioMedicine Online (Elsevier Science) . Mar2018, Vol. 36 Issue 3, p269-276. 8p. - Publication Year :
- 2018
-
Abstract
- This retrospective cohort analysis compared the developmental competence of cryopreserved day-4 and 5 blastocysts, and investigated the effect of progesterone administration duration on the success of artificial frozen embryo transfers. Between October 2015 and March 2016, 868 intracytoplasmic sperm injection blastocyst cryo-all cycles were carried out, with 586 subsequently undergoing frozen embryo transfer. Of these, 243 were day-5 single blastocyst transfers (SBT) and 152 were day-4 SBT. Day-4 blastocysts were transferred on day-5 progesterone (day-4 group) and day-5 blastocysts were transferred on day-5 (short-protocol day-5 sub-group, n = 104) or day-6 (standard-protocol day-5 sub-group, n = 139) progesterone. Although more blastocysts were transferred in the standard-protocol day-5 sub-group ( P = 0.009), pregnancy, clinical pregnancy and live birth rates were similar to those of the day-4 group, but were significantly lower in the short-protocol day-5 sub-group ( P = 0.004, P = 0.008 and P = 0.02 respectively). For optimal outcomes, day-4 blastulating embryos should be prioritized for transfer on day 5 of progesterone and for day-5 blastocysts, transfer should be delayed by 1 day. The retrospective analysis and lack of adjustment for all known confounding variables limit the study. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14726483
- Volume :
- 36
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Reproductive BioMedicine Online (Elsevier Science)
- Publication Type :
- Academic Journal
- Accession number :
- 127921261
- Full Text :
- https://doi.org/10.1016/j.rbmo.2017.12.009