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Trichiconlides C[sbnd]F, four new limonoids with 1,2-seco phragmalin-type carbon skeleton from the fruits of Trichilia connaroides.
- Source :
-
Fitoterapia . Mar2018, Vol. 125, p72-77. 6p. - Publication Year :
- 2018
-
Abstract
- Phytochemical investigation of the fruits from Trichilia connaroides led to the isolation of four rare 1,2- seco phragmalin-type limonoids ( 1 – 4 ) with C-7/28 δ -lactone ring along with two known triterpenoids ( 5 – 6 ). An oxygen bridge between C-1 and C-2 formed an rare 9- oxa -tricyclo[3.3.2.1 7,10 ]undecane-2-ene moiety in structure of 1 and 2 , and 3 – 4 possessed a bicyclo[5.2.1 4,10 ]decane skeleton. Their structures were established based on extensive spectroscopic methods and their absolute configurations of 1 were confirmed by TDDFT/ECD calculation and comparative analysis. Compounds 5–6 showed moderate inhibitory effects on Hela tumor cell lines with inhibition ratio values of 83.8% and 87.1% at concentration 40 μM, respectively. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALTERNATIVE medicine
*ANTINEOPLASTIC agents
*BIOLOGICAL models
*PHYSICAL & theoretical chemistry
*DOSE-effect relationship in pharmacology
*FRUIT
*MEDICINAL plants
*SPECTRUM analysis
*PHYTOCHEMICALS
*PLANT extracts
*DESCRIPTIVE statistics
*IN vitro studies
*PHARMACODYNAMICS
CERVIX uteri tumors
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 125
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 127871975
- Full Text :
- https://doi.org/10.1016/j.fitote.2017.12.023