Phyllaciduloids A–D: Four new cleistanthane diterpenoids from Phyllanthus acidus (L.) Skeels.

Four new cleistanthane diterpenoids, phyllaciduloids A–D ( 1 – 4 ), were isolated from the roots and stems of Phyllanthus acidus (L.) Skeels (Phyllanthaceae). Their structures were elucidated on the basis of extensive spectroscopic analysis. Phyllaciduloids B–D ( 2 – 4 ) present in their structures with ether bond between C-7 and C-16, which were rarely reported. All the isolates were evaluated for their cytotoxic activities against five human cancer cell lines. [ABSTRACT FROM AUTHOR]