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The Effect of D-Methionine on Cochlear Oxidative State with and without Cisplatin Administration: Mechanisms of Otoprotection.
- Source :
-
Journal of the American Academy of Audiology . Apr2003, Vol. 14 Issue 3, p144-156. 13p. 1 Chart, 4 Graphs. - Publication Year :
- 2003
-
Abstract
- D-methionine (D-met) protects against cisplatin (CDDP) ototoxicity, but the mechanisms are not well understood. This study investigated D-met protection of cochlear oxidative state as measured by superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), and malondiadehyde (MDA) levels. The design comprised four groups of five rats each: (1) a saline control group, (2) a CDDP-only-treated group, (3) a CDDP group pretreated with D-met, and (4) a group receiving only D-met. Auditory brainstem response testing (ABR) was performed before and 3 days after injection. CDDP alone caused marked hearing loss; significantly reduced SOD, CAT, and GR levels; and increased MDA levels, but D-met pretreatment protected against these changes. These studies suggest that D-met protects cochlear antioxidant enzyme levels from CDDP-induced decrements. The excellent correlation of enzyme levels with hearing loss and weight loss suggests that antioxidant enzyme level protection may underlie, at least in part, D-met's otoprotective action. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10500545
- Volume :
- 14
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of the American Academy of Audiology
- Publication Type :
- Academic Journal
- Accession number :
- 12783061