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An Esculetin--Cobalt(III) Archetype for Redox-Activated Drug Delivery Platforms with Hypoxic Selectivity.
- Source :
-
European Journal of Inorganic Chemistry . 2/7/2018, Vol. 2018 Issue 5, p612-616. 5p. - Publication Year :
- 2018
-
Abstract
- The motivation of this work was to probe whether coordination of esculetin to cobalt(III) could lead to a complex with the required properties to function as a redox-activated drug delivery platform, selective for hypoxic environments. The complex [Co(esc)(py2en)]ClO4·(CH3OH)2 (1) was obtained and fully characterized by CHN elemental analysis, single-crystal Xray diffractometry, UV/Vis and fluorescence spectroscopy, and ESI mass spectrometry. The redox behavior of 1 was evaluated by cyclic and square wave voltammetry analyses in MeCN and PBS buffer, which revealed distinct potentials for the Co3+/Co2+ processes in aqueous and organic solutions. In PBS, the potential is within the accepted ideal range (-0.2 to -0.4 V vs. SHE) for reduction in biological systems. Thus, a selective release of the coumarin ligand in a hypoxic environment upon reduction was simulated by investigating reactions of 1 with sodium dithionite in argon-, air-, and O2-saturated atmospheres. An [O2]-dependent dissociation of esculetin was monitored over a 72 h period at 25 °C by UV/Vis spectroscopy and confirmed by fluorescence spectroscopy and ESI-MS data. These results provide strong evidence of a hypoxia-selective, redox-activated mechanism for the release of esculetin from this cobalt(III) complex. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14341948
- Volume :
- 2018
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- European Journal of Inorganic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 127793542
- Full Text :
- https://doi.org/10.1002/ejic.201701251