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Impact of Oral and Gastrointestinal Mucositis on Body Weight Alterations during Hematopoietic Stem Cell Transplantation.
- Source :
-
Nutrition & Cancer . Feb/Mar2018, Vol. 70 Issue 2, p241-248. 8p. - Publication Year :
- 2018
-
Abstract
- The aim of this study was to evaluate whether digestive tract mucositis is a predictive factor for body weight (BW) alterations during hematopoietic stem cell transplantation (HSCT). Data about characteristics of transplantation, initial nutritional conditions and gastrointestinal mucositis were collected from adult patients (n= 105) who underwent autologous and allogeneic HSCT. Oral mucositis (OM) was not a predictive factor for BW loss, but it was an independent factor for BW gain in autologous HSCT (β = 0.329,P= 0.021). Busulfan-fludarabine conditioning regimen (β = 1.531,P= 0.011) and gender (β = 1.109,P= 0.038) were significant independent risk factors for BW loss in allogeneic HSCT. Overall survival (OS) was significantly affected by the duration of OM in autologous HSCT (HR = 1.243,P= 0.008). In allogeneic HSCT, BW loss (HR = 1.308,P= 0.049) and diarrhea (HR = 1.139,P= 0.012) interfered significantly with OS. In conclusion, OM was not a risk factor for BW loss, but it influenced BW gain and had a negative impact on OS in autologous HSCT patients. Intestinal mucositis explained partially the BW loss and had a negative impact on OS in allogeneic HSCT. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01635581
- Volume :
- 70
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Nutrition & Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 127727756
- Full Text :
- https://doi.org/10.1080/01635581.2018.1412476