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The JAK2/STAT3 pathway is involved in the anti‐melanoma effects of atractylenolide I.
- Source :
-
Experimental Dermatology . Feb2018, Vol. 27 Issue 2, p201-204. 4p. - Publication Year :
- 2018
-
Abstract
- Abstract: In this study, we aimed to investigate the anti‐melanoma effects and the JAK2/STAT3 pathway‐related mechanism of action of atractylenolide I in human melanoma cells. Our results showed that atractylenolide I effectively reduced viability, induced apoptosis and inhibited migration of melanoma cells. Meanwhile, atractylenolide I decreased the protein expression levels of phospho‐JAK2 and phospho‐STAT3, and in turn downregulated the mRNA levels of STAT3‐targeted genes, including Bcl‐xL, MMP‐2 and MMP‐9. Furthermore, the cytotoxic effect of atractylenolide I was attenuated in STAT3‐overactivated A375 cells. These findings indicate that inhibition of JAK2/STAT3 signalling contributes to the anti‐melanoma effects of atractylenolide I. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09066705
- Volume :
- 27
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Experimental Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 127679196
- Full Text :
- https://doi.org/10.1111/exd.13454