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Estrogen modulates ghrelin expression in the female rat stomach
- Source :
-
Peptides . Feb2004, Vol. 25 Issue 2, p289. 9p. - Publication Year :
- 2004
-
Abstract
- Ghrelin was recently identified as an endogenous ligand for GH secretagogue receptor. In this study, we investigated the effects of ovariectomy on the numbers of ghrelin-immunopositive and -expressing cells, ghrelin mRNA levels, and plasma ghrelin concentrations in 4- and 9-week-old female rats. Three days after ovariectomy, the number of ghrelin cells and plasma ghrelin level significantly increased in both 4- and 9-week-old rats and the ghrelin mRNA level also increased in 4-week-old rats. These responses were reversed by 17β-estradiol replacement. We also found that ghrelin-immunopositive cells express estrogen receptor α. These results suggested that estrogen is involved in the regulation of ghrelin expression. [Copyright &y& Elsevier]
- Subjects :
- *ESTROGEN receptors
*STEROID hormones
*LABORATORY rats
*MESSENGER RNA
Subjects
Details
- Language :
- English
- ISSN :
- 01969781
- Volume :
- 25
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Peptides
- Publication Type :
- Academic Journal
- Accession number :
- 12746737
- Full Text :
- https://doi.org/10.1016/j.peptides.2003.12.020