Synthesis of Some New Polyfunctionalized Pyridines.

5‐Methyl‐2,4‐dihydro‐3H‐pyrazol‐3‐one and/or 5‐methyl‐2‐phenyl‐2,4‐dihydro‐3H‐pyrazol‐3‐one was reacted with arylidenemalononitrile in the presence of sodium alkoxide to give 2‐amino‐6‐alkoxy‐4‐arylpyridine‐3,5‐dicarbonitrile <bold>4a–e</bold> instead of the reported pyrazolo[3,4‐b]pyridine‐5‐carbonitriles. The same products <bold>4a–e</bold> were prepared via reaction of arylidenemalononitrile with sodium alkoxide in an appropriative alcohol. However, the new synthetic route for preparation of their positional isomer 4‐amino‐6‐alkoxy‐2‐arylpyridine‐3,5‐dicarbonitrile <bold>7a–j</bold> has been achieved via reaction of 2‐aminoprop‐1‐ene‐1,1,3‐tricarbonitrile with different aromatic aldehydes under the same conditions. [ABSTRACT FROM AUTHOR]