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Medical genetics: A marker for Stevens-Johnson syndrome.
- Source :
-
Nature . 4/1/2004, Vol. 428 Issue 6982, p486-486. 1p. - Publication Year :
- 2004
-
Abstract
- Stevens-Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and Stevens-Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures. It should be possible to exploit this association in a highly reliable test to predict severe adverse reaction, as well as for investigation of the pathogenesis of Stevens-Johnson syndrome. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00280836
- Volume :
- 428
- Issue :
- 6982
- Database :
- Academic Search Index
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 12728781
- Full Text :
- https://doi.org/10.1038/428486a