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Catalyst-free synthesis of 2,3-dihydrobenzofurans through [4+1] cycloaddition of ortho-hydroxyphenylsubstituted para-quinone methides and sulfur ylides.
- Source :
-
Tetrahedron . Feb2018, Vol. 74 Issue 5, p600-605. 6p. - Publication Year :
- 2018
-
Abstract
- An efficient [4+1] cycloaddition of ortho -hydroxyphenylsubstituted para- quinone methides and sulfur ylides was achieved under the catalyst-free condition. With this developed protocol, a series of trans -2,3-dihydrobenzofurans were obtained in excellent yields (up to 99%) with high diastereoselectivities (>20:1 dr). The usefulness of the protocol was also demonstrated by the versatile conversions of the 2,3-dihydrobenzofurans into other functionalized benzofurans. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00404020
- Volume :
- 74
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Tetrahedron
- Publication Type :
- Academic Journal
- Accession number :
- 127137056
- Full Text :
- https://doi.org/10.1016/j.tet.2017.12.038