The role of glutamate and its receptors in central nervous system in stress-induced hyperalgesia.

Purpose:To explore the potential mechanisms of glutamate and its receptors in stress-induced hyperalgesia. Materials and methods:The stress-induced hyperalgesia, glutamate and its receptors are listed as key items in the pubmed database and the related articles are searched. Results:Glutamate level is increased under stress and associated with stress-induced hyperalgesia. Moreover, the role of glutamate in stress-induced hyperalgesia depends on its subtypes of its receptors. Conclusions:Increased glutamate during stress connect with ionotropic glutamate receptors can prompt hyperalgesia, but connect with metabotropic glutamate receptors can inhibit hyperalgesia. [ABSTRACT FROM AUTHOR]