山东沿海地区成年女性骨密度调查及骨量分析.

Objective To establish and evaluate the bone mineral density (BMD) reference database of multiple skeletal regions, which would be useful for diagnosis of osteoporosis (OP) in women. Methods Healthy females aged 25-35 years were selected. BMD of the lumbar spine (L2, L3, and L4), the left hip (femoral neck, Ward’s triangle, and the greater trochanter was measured using dual-energy X-ray absorption (DXA, Lunar i and Lunar NT, USA, respectively). The calibration equations were established. BMD between women in Qingdao and in Yantai was compared before and after the calibration. The best fitting model equations were found and the reference database was established. Prevalence of OP was analyzed according to the database. Results (1) BMD result examined with Lunar i and Lunar NT showed significant linear relationship. (2) BMD after calibration in 6 skeletal regions showed change with aging. BMD reference database of women in Shandong’s coastal area was established by cubic regression equation. The peak BMD appeared at 20-40 years old and followed by a linear decrease after 40 years old. (3) Based on this database, the prevalence of OP increased with age in women aged from 50 to 89 who had medical examination from 2005 to 2012. The prevalence was lower than other cities. The detecting rates of OP were higher than that provided by the Lunar i reference database. Conclusion This study establishes the BMD reference database in women in Shandong coastal area, which can be used as reference standard for OP diagnosis in the region. [ABSTRACT FROM AUTHOR]